Silibinin in cancer therapy: A promising prospect

The potential anti-cancer properties of natural plant compounds have elicited widespread interest in recent times since it is believed that they can substantially contribute to the development of newer and more effective anti-cancer therapies. Silibinin, a natural flavonoid, has demonstrated chemopreventive properties against many cancer types. A deeper understanding of the signaling pathways modulated by silibinin is important to realize its potential in developing targeted cancer therapies. This review summarizes the recent advances in understanding the molecular mechanisms of silibinin-induced apoptosis in various cancer types.