Open AccessAmyloid Peptide Self-Assembly in Protic Ionic Liquids
Author(s) -
Natalie Debeljuh,
Colin J. Barrow,
Nolene Byrne
Publication year - 2013
Language(s) - English
Resource type - Conference proceedings
DOI - 10.17952/23aps.2013.122
Subject(s) - ionic liquid , peptide , self assembly , amyloid (mycology) , ionic bonding , chemistry , computer science , combinatorial chemistry , nanotechnology , materials science , organic chemistry , ion , biochemistry , inorganic chemistry , catalysis
Overall, this thesis presents the novel approach of using carefully selected PILs to both control amyloid fibril formation and inhibit/dissolve Aβ fibrils through induced helical transitions. These results provide insights into future PIL-mediated protein studies and the potential application of PILs in AD pathogenesis.
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