Open AccessHippocampal Volume in Type 1 Diabetes
Author(s) -
Michael Murray,
Molly Stanley,
Heather M. Lugar,
Tamara Hershey
Publication year - 2014
Publication title -
us neurology
Language(s) - English
Resource type - Journals
eISSN - 1758-4019
pISSN - 1758-4000
DOI - 10.17925/usn.2014.10.01.68
Subject(s) - hippocampal formation , medicine , hippocampus , hypoglycemia , glycemic , type 2 diabetes , neuroscience , diabetes mellitus , endocrinology , psychology
The hippocampus plays an important role in human memory and is known to be vulnerable to extreme hyperglycemia and hypoglycemia in animal models of type 1 diabetes. Within humans with type 1 diabetes, exposure to glycemic extremes has been associated with alterations in hippocampal structure and in memory function, but results are inconsistent. It has been hypothesized that the effects of hypoglycemia and hyperglycemia on the hippocampus may depend on when during neurodevelopment these extremes occur, possibly explaining some of these inconsistencies. However, data addressing this concept are limited. We review here the existing literature on this complex topic and suggest future avenues of required research.