Seroprevalence of Hepatitis B and C in Patients With Hemophilia: A Single-Centre Descriptive Study

Hemophilia population is one of the most endangered people, being infected with blood-borne diseases via blood (or its products) transfusion. The aims of this study was to evaluate and compare the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and HBV/HCV co-infection in hemophilia patients as the population at risk of viral hepatitis infections. One hundred and forty-six patients with hemophilia who referred to the two main hospitals of Fasa City, Fars Province, Iran during 2007-2013 were selected (male to female ratio of approximately 1:1). These patients were checked for HBV and HCV infection using Hepatitis B surface antigen (HBsAg) and anti-HCV antibody (IgG) assay through ELISA method. SPSS software was used for data analyses. Our sample comprised 57% men and 43% women with the mean age of 20.4 ± 11.9 years (age range from 0.08-84 years). The prevalence of HBV and HCV infection in patients with hemophilia were 1.4% (2 patients) and 8.9% (13 patients), respectively. No patient with HBV/HCV coin-fection was detected and also, there were no correlation between gender and having splenectomy with the prevalence of both HBV and HCV infections. The prevalence of HBV and HCV infections among patients with hemophilia found in this study was in line with approximately all other previous reports from other regions of Iran and this means that both HCV and HBV can be a serious problem in patients with hemo-philia. However, further studies in other regions with higher patient number and other detecting methods are highly recommended. Hemophilia A and B are rare hereditary bleeding disorders , which are caused by mutations in the factor VIII and IX genes (1). Hemophilia could be treated with the whole blood or blood products (2). However, blood transfusion is the main risk factor for transmitting some viruses, such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) (3). Hepatitis B, caused by HBV, is the most prevalent cause of human liver disease (4), while, hepatitis C, caused by HCV, is one of the most common chronic blood-borne infections (5). The aims of this study were to determine and compare the prevalence of HBV, HCV infections and HBV/HCV coinfection in patients with hemophilia living in Fasa, southern part of Iran. In this cross sectional single-centre descriptive study, 146 patients diagnosed with hemophilia A, were enrolled. They were treated and registered from 2007-2012 and referred to two main …