NeuN Expression Alterations in the Hippocampus Following Ecstasy Treatment | Zendy

Fahimeh Ghasemi Moravej | Zendy; Iraj Amiri | Zendy; ‬Siamak Shahidi | Zendy; Mehdi Mehdizadeh | Zendy; Asrin Rahimi | Zendy; B. Esmaeilzadeh | Zendy; Sara Soleimani Asl | Zendy

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NeuN Expression Alterations in the Hippocampus Following Ecstasy Treatment

Author(s) -

Fahimeh Ghasemi Moravej,

Iraj Amiri,

‬Siamak Shahidi,

Mehdi Mehdizadeh,

Asrin Rahimi,

B. Esmaeilzadeh,

Sara Soleimani Asl

Publication year - 2016

Publication title -

avicenna journal of neuro psych physiology

Language(s) - English

Resource type - Journals

eISSN - 2383-2444

pISSN - 2383-2436

DOI - 10.17795/ajnpp-40463

Subject(s) - ecstasy , neun , hippocampus , neuroscience , expression (computer science) , psychology , medicine , computer science , psychiatry , immunohistochemistry , programming language

Background: The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. Objectives: Due to the eect of neurogenesis on memory and learning, in this study, we investigated the eects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Methods: Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Results: Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. Conclusions: These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis.

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