Albino Farelerde Fenpiroksimat Akarisiti Tarafından Teşvik Edilen Toksisiteye Karşı Fındığın Koruyucu Rolünün Araştırılması | Zendy

Kübra SABAH | Zendy; Güray Demirtaş | Zendy; Ali Acar | Zendy; Baran SEVEN | Zendy; Emine Yalçın | Zendy; Kürşad Yapar | Zendy; Kültiğin Çavuşoğlu | Zendy

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Albino Farelerde Fenpiroksimat Akarisiti Tarafından Teşvik Edilen Toksisiteye Karşı Fındığın Koruyucu Rolünün Araştırılması

Author(s) -

Kübra SABAH,

Güray Demirtaş,

Ali Acar,

Baran SEVEN,

Emine Yalçın,

Kürşad Yapar,

Kültiğin Çavuşoğlu

Publication year - 2016

Publication title -

cumhuriyet science journal

Language(s) - English

Resource type - Journals

ISSN - 1300-1949

DOI - 10.17776/csj.77232

Subject(s) - micronucleus , body weight , toxicology , biology , chemical agents , andrology , traditional medicine , toxicity , micronucleus test , medicine , endocrinology , biochemical engineering , engineering

Ozet. Bu calismada, Fenpiroksimat akarisitinin Swiss albino farelerde olusturdugu fizyolojik ve genotoksik etkiler ile bu etkilere karsi findigin koruyucu rolu arastirilmistir. Fareler rastgele bir (1) kontrol ve bes (5) uygulama olmak uzere toplam alti (6) gruba ayrilmistir. Fizyolojik etkiler canli agirlik, karaciger ve bobrek agirliklarinin olculmesiyle, genotoksik etkiler ise mikronukleus (MN) ve kromozomal hasar sayilarinin belirlenmesiyle tespit edilmistir. Sonucta Fenpiroksimat uygulamasinin kontrol grubuna gore canli ve organ agirliklarinda azalisa, MN ve kromozomal anormallik sayilarinda bir artisa sebep oldugu gozlenmistir. Findik ile besleme Fenpiroksimat’in soz konusu olumsuz etkilerini iyilestirerek, kontrol grubu kadar olmasa da soz konusu parametrelerde tekrar bir iyilesmeye sebep olmustur. Sonuc olarak, findik pestisitler gibi kimyasal ajanlarin sebep oldugu toksisitenin azaltilmasinda “toksisite sinirlayici” bir antioksidan urun olarak kullanilabilir. Anahtar Kelimeler: Fenpiroksimat, kromozomal anormallikler, mikronukleus, Fizyoloji Swiss albino fare. Abstract. In this study, the physiological and genotoxic effects of Fenpyroximate acaricide on Swiss albino mice, and the protective role of nut against these effects were investigated. Mice were randomly divided into six (6) groups, consisting of one (1) control and five (5) experimental groups. Physiological effects were determined by measuring the weight of body, liver and kidneys, and genotoxic effects were determined with identification of micronucleus (MN) frequency and the number of chromosomal damage. Compared to the control group, it was observed a decrease in organ and body weight, and an increase in the frequency of MN and the number of chromosomal abnormalities in Fenpyroximate experiment group. Feed with nut improved negative effects of Fenpyroximate, although not as much control group has led to an improvement in these parameters again. As a result, nut can be used to reduce toxicity stimulated by chemical agents such as pesticides and used as “toxicity restrictive” an antioxidants product. Keyword: Fenpyroximate, chromosomal aberrations, micronucleus, physiology, Swiss albino mice.

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