Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts, endometrioid and clear cell ovarian cancer | Zendy

Aleksandra Brucka | Zendy; Krzysztof Szyłło | Zendy

Open Access

Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts, endometrioid and clear cell ovarian cancer

Author(s) -

Aleksandra Brucka,

Krzysztof Szyłło

Publication year - 2013

Publication title -

ginekologia polska

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 21

eISSN - 2543-6767

pISSN - 0017-0011

DOI - 10.17772/gp/1587

Subject(s) - pten , immunohistochemistry , medicine , clear cell , ovarian cancer , pathology , endometrial cancer , endometrium , cancer , oncology , biology , apoptosis , pi3k/akt/mtor pathway , biochemistry

Endometrioid and clear cell ovarian adenocarcinomas are suspected to derive from ectopic endometrial foci. The aim of the study was to determine PTEN and MMP-2 immunoexpression in endometrial ovarian cysts, endometrioid and clear cell ovarian carcinomas and to assess the relationship between the abovementioned values and clinical data of patients in order to find the marker of increased risk of malignant proliferation based on ovarian endometriotic lesions. Detailed analysis of the collected data was conducted to investigate the correlation between immunohistochemical expression of the examined antigens, histopathological diagnosis and clinical condition of patients.

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