Open AccessTyrosyl-tRNA Synthetase and its Separated Domains are Suppositional Components of Prostate Cancer Pathogenesis
Author(s) -
Matic Grom,
L.F. Yakovenko,
Л. Л. Сидорик,
O. Kornelyuk,
V. Grygorenko,
М. В. Вікарчук
Publication year - 2016
Publication title -
bulletin of taras shevchenko national university of kyiv series problems of physiological functions regulation
Language(s) - English
Resource type - Journals
eISSN - 2616-6410
pISSN - 1728-2624
DOI - 10.17721/2616_6410.2016.20.38-44
Subject(s) - pathogenesis , transfer rna , prostate cancer , cancer , genetics , biology , computational biology , cancer research , gene , immunology , rna
Elevated levels of autoantibodies against tyrosyl-tRNA synthease and its separated fragments enriched with proinflammatory and angiogenic properties in sera of patients with prostate cancer were shown. In serum samples of patients the highest levels of autoantibodies against C-terminal domain were observed. Minimal autoreactivity among persons with oncopathology was shown against N-terminal domain of tyrosyl-tRNA synthetase.
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