CHARACTERISTICS OF IMMUNE RESPONSE UNDER EXPERIMENTAL MODELS OF ACID BURNS OF THE ESOPHAGUS | Zendy

Т.V. Koval | Zendy; T. Ischuk | Zendy; Ya. Raetska | Zendy

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CHARACTERISTICS OF IMMUNE RESPONSE UNDER EXPERIMENTAL MODELS OF ACID BURNS OF THE ESOPHAGUS

Author(s) -

Т.V. Koval,

T. Ischuk,

Ya. Raetska

Publication year - 2016

Publication title -

bulletin of taras shevchenko national university of kyiv series biology

Language(s) - English

Resource type - Journals

ISSN - 1728-2748

DOI - 10.17721/1728_2748.2016.72.52-55

Subject(s) - esophagus , immune system , humoral immunity , immunity , regeneration (biology) , immunology , medicine , burn injury , biology , surgery , microbiology and biotechnology

It is well known that the immune system is actively involved in the regeneration and healing process of burn wounds. However, unanswered questions remain about the role of humoral immunity in the mechanisms of healing and complications of burn wounds. We have developed an experimental model of the acid burns of the esophagus (ABE) corresponding esophageal burns in children 1-8 years. We studied the features of humoral immunity in rats with AВE, with the observed reduction of IgG and increase levels of medium and low circulating immune complexes (CIC) on the first day after the burn of the esophagus. On 21st day after the burn, we observed an increase in the concentration of IgG and a slight accumulation of medium- and low-CIC. Studied indicators can be used for the differentiation of ABE.

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