Subgingival application of 25% metronidazole gel, 1% chlorhexidine gel as adjunctive therapy to scaling and root planing in treatment of chronic periodontitis

Objectives: The aim of this study was to compare the clinical effect of subgingival application of 25% metronidazole gel or 1% chlorhexidine gel as an adjunctive to scaling and root planing over a root planing alone. Materials and Methods: Ten adults (6 females and 4 males) with an age range of (30-60) years, each with at least three non-adjacent periodontally involved teeth with a probing pocket depth of ≥ 5mm and bleeding on probing participated in this randomized, split mouth, clinical study. A total of (394) sites were included in the study, the selected sites in each patient were divided into: Group 1 (root planing plus 25% metronidazole gel), Group 2 (root planing plus 1% chlorhexidine gel) and Group 3 (root planing alone).Clinical evaluation included: plaque index PLI (Silness and Loe, 1964), gingival index GI (Loe and Silness, 1963), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level