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Pycnanthus angolensis (Welw.) Warb and Byrophyllum pinnatum (Lam.) Oken are two herbal recipes employed in native medicine for the treatment /management of gastrointestinal disorders, skin infections and more especially cancers, wounds and many other inflammatory conditions. Before now, seven compounds ( NG-1b, NG-2 , NG-3b, NG-4c, NG-5a , KF - 1a and KF - 2) have been obtained from the extracts of these plants by column and /or preparative thin - layer chromatographies. The search for new and more active antioxidant agents necessitated the screening of these compounds for potential activity. Generally the isolates gave (IC 50 ) of between 0.50and 0.60 μg mL -1 .However, NG-1b demonstrated a significant activity at 0.48 μg mL -1 which compare favourably with that shown by Vitamin A (a standard antioxidant drug) at 0.49 μg mL -1 . These compounds, most especially NG-1b could be further worked on with the aim of improving on the observed antioxidant activity through in-vitro structural activity relationship studies (SARS) and probably in-vivo clinical trials.

ANTIOXIDANT ACTIVITY OF COMPOUNDS ISOLATED FROM PYCNANTHUS ANGOLENSIS (WELW.) WARB AND BYROPHYLLUM PINNATUM (LAM.) OKEN