Eaton’s Reagent Catalyzed Synthesis, Invitro α-Amylase Inhibitory Activity and Molecular Docking Study of some Schiff’s Bases as Diabetic-II Inhibitors | Zendy

Sushma S. Kauthale | Zendy; S. U. Tekale | Zendy; Alexander Rode | Zendy; Rajendra Patil | Zendy; Jaiprakash N. Sangshetti | Zendy; László Kótai | Zendy; R. P. Pawar | Zendy

Open Access

Eaton’s Reagent Catalyzed Synthesis, Invitro α-Amylase Inhibitory Activity and Molecular Docking Study of some Schiff’s Bases as Diabetic-II Inhibitors

Author(s) -

Sushma S. Kauthale,

S. U. Tekale,

Alexander Rode,

Rajendra Patil,

Jaiprakash N. Sangshetti,

László Kótai,

R. P. Pawar

Publication year - 2019

Publication title -

european chemical bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.131

H-Index - 5

ISSN - 2063-5346

DOI - 10.17628/ecb.2019.8.356-362

Subject(s) - reagent , docking (animal) , chemistry , in vitro , catalysis , amylase , inhibitory postsynaptic potential , combinatorial chemistry , stereochemistry , enzyme , biochemistry , organic chemistry , biology , medicine , endocrinology , nursing

A series of Schiff’s bases of p-tolylsulphonyl hydrazide were synthesized by using Eaton's reagent under solvent-free condition, characterized by spectroscopic data and for evaluated α-amylase inhibitory activity in vitro . Four among the studied compounds exhibited varying degrees of α-amylase inhibitory activity with IC 50 values in the range of 115.48 to 169.42 µg mL -1 . The observed results were supported by the molecular docking study performed to understand the binding interaction of the title compounds with the active site of α-amylase enzyme. Results suggest that Schiff's bases of p-tolylsulphonyl hydrazide derivatives can act as potential antidiabetic drugs.

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