Open AccessCONDENSATION REACTION BETWEEN 3-ACETYLCOUMARINE AND ARYL ALDEHYDES IN THE PRESENCE OF L-PROLINE
Author(s) -
Malihe Kamalpour,
Farahnaz K. Behbahani
Publication year - 2019
Publication title -
european chemical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.131
H-Index - 5
ISSN - 2063-5346
DOI - 10.17628/ecb.2019.8.336-338
Subject(s) - salicylaldehyde , coumarin , aldehyde , yield (engineering) , chemistry , chalcone , proline , catalysis , condensation , aryl , condensation reaction , organic chemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry , amino acid , schiff base , materials science , biochemistry , physics , alkyl , metallurgy , thermodynamics
3-Acetylcoumarine and a series a coumarin-chalcone hybrid compounds have been synthesized in good- to-excellent yields using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester to afford 3-acetylcoumarine and the product has been treated with an aromatic aldehyde using L-proline as a bioorganic catalyst to yield 1-(3-coumarinyl)-3-aryl-2-propen-1-one (3-cinnamoylcoumarins).
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