SYNTHESIS AND ANTIMICROBIAL SCREENING OF 5-(SUBSTITUTED PHENYL)-N-(2-OXO-2-(SUBSTITUTED PHENYL)ETHYL)-N-METHYLFURAN-2-SULFONAMIDE DERIVATIVES

We synthesized substituted furansulfonamide compounds and developed reaction conditions for a series of 5-(substituted phenyl)-N-(2-oxo-2-(substituted phenyl)ethyl)-N-methylfuran-2-sulfonamide derivatives ( 4a - 4m ). We have optimized methodology for targets from milligram scale to multi gram scale. The structure of synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and purity was checked by HPLC. All the synthesized final compounds (4a-4m) are screened for antimicrobial activity (minimum  inhibitory concentration) against a series of strains of Bacillus subtillis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity. The results of antimicrobial screening data revealed most of compounds (4a-4m) showed moderate to promising microbial inhibitions.