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Novel 4-substituted pyran-2-one derivatives were synthesized by condensation of 6-methylpyran-2-ones and corresponding 2-aminobenzothiazoles. Condensation of 4-chloro-6-methyl-2H-pyran-2-one  2 and 2-aminobenzothiazoles 3(a-c) afforded corresponding 4-(2-benzothiazolylamino)-6-methyl-2H-pyran-2-one 4a, 4-(4-methyl-2-benzothiazolylamino)-6-methyl-2H-pyran-2-one 4b and 4-(5,6-dimethyl-2-benzothiazolylamino)-6-methyl-2H-pyran-2-one 4c . By condensation of 4-chloro-3-nitro-6-methyl-2H-pyran-2-one 6a and 2-aminobenzothiazoles 3(a, d), 4-(2-benzothiazolylamino)-3-nitro-6-methyl-2H[1]-pyran-2-one 4d and  4-(6-ethoxy-2-benzothiazolylamino)-3-nitro-6-methyl-2H[1]-pyran-2-one 4e were synthesized. The synthesized products were characterized on the basis of IR, 1 H-NMR and 13 C-NMR spectra. The antibacterial activity is examined by measuring the inhibition zones around the disks impregnated with the corresponding product solutions in N,N-DMF concentration 2 mg/mL , 4 mg/mL and 6 mg/mLand results are reported.

SYNTHESIS OF SOME NEW 4-(BENZOTHIAZOLYLAMINO)-PYRAN-2-ONE DERIVATIVES AND THEIR ANTIBACTERIAL ACTIVITY