Open AccessCYP1A1 and CYP1B1-Mediated Biotransformation of the Antitrypanosomal Methamidoxime Prodrug DB844 Forms Novel Metabolites Through Intramolecular Rearrangement
Author(s) -
Wujian Ju,
Sihyung Yang,
John H. Ansede,
Chad E. Stephens,
Arlene S. Bridges,
Robert D. Voyksner,
Mohamed A. Ismail,
David W. Boykin,
Richard R. Tidwell,
James Edwin Hall,
Michael Zhuo Wang
Publication year - 2014
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/78wh-1w29
Subject(s) - biotransformation , prodrug , intramolecular force , chemistry , stereochemistry , pharmacology , biochemistry , biology , enzyme