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Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p
Author(s) -
Tarık Onur Tiryaki,
Sezen Genc,
Gulcin Bagatir Ozan,
Kıvanç Çefle,
Şükrü Palanduz,
Gülçin Yeğen,
Öner Doğan,
Meliha Nalçacı
Publication year - 2018
Publication title -
medical science and discovery
Language(s) - English
Resource type - Journals
ISSN - 2148-6832
DOI - 10.17546/msd.413622
Subject(s) - medicine , chronic lymphocytic leukemia , autoimmune hemolytic anemia , hemophagocytic lymphohistiocytosis , prolymphocytic leukemia , immunology , leukemia , disease , anemia
Chronic lymphocytic Leukemia (CLL) is the most common form of leukemia in adults. Clinical findings may broad range vary. Detecting some deletions using the FISH method may help us to foresee the progression of the disease and to choose a better treatment method in healing the patient. In this case report, we will present you a CLL patient with t(7;14), t(14;19) and  17p deletions, which are known for bad prognosis, developing autoimmune hemolytic anemia which is refractor to the treatment. This patient unfortunately died due to a clinical form of hemophagocytic syndrome including prolymphocytic transformation.

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