Effect of Antiepileptic drugs on lipid profile in children with Epilepsy | Zendy

Dr Jayashree Nadkarni | Zendy; Dr Deepak Kumar Uikey | Zendy; D Sharma | Zendy; Dr Rashmi Dwivedi | Zendy

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Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

Author(s) -

Dr Jayashree Nadkarni,

Dr Deepak Kumar Uikey,

D Sharma,

Dr Rashmi Dwivedi

Publication year - 2014

Publication title -

international journal of medical research and review

Language(s) - English

Resource type - Journals

eISSN - 2321-127X

pISSN - 2320-8686

DOI - 10.17511/ijmrr.2014.i02.09

Subject(s) - epilepsy , phenytoin , medicine , valproic acid , lipid profile , analysis of variance , significant difference , pediatrics , cholesterol , psychiatry

Objective: The study evaluated the effect of antiepileptic drugs on lipid profile in children with epilepsy. Demographic profile and the seizure pattern of CWE were also studied. Material and method: 95 children aged between 2-15 years with confirmed diagnosis of primary epilepsy who were on AED for at least 3 months were the cases and 50 normal healthy children of similar age group were the controls. Children with BMI >95th entile were excluded. The cases were categorized in three groups depending upon whether they were taking either phenytoin, valproic acid alone or in combination. Result: The Levene‘s test for homogeneity of variance indicated a significant difference in variance between the cases and control group in serum TGs, LDL-C and VLDL-C. The t-test showed a significant difference in means among cases and controls in HDL-C, LDL-C levels and the risk ratio. Conclusion: We recommend a need for careful monitoring of lipid profile in children with epilepsy receiving antiepileptic drugs

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