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The communication between the digestive tract and the brain is an important aspect to the regulation and maintenance of its functionality. This communication is made by a network of signals that the brain sends to the gastrointestinal tract and vice-versa through the gut-brain axis. These signals can be direct or indirect, direct is a signal sent by the pathogen to the brain, while indirect is a signal originated from the alterations that the pathogen triggers.

Intestine microbiota and neurodegenerative diseases: Can microbiota affect the brain?