Cytotoxic mechanism of Bothrops jararaca venom mediated by mitochondrial depolarization | Zendy

Moras Ana Moira | Zendy; Luiza Steffens Reinhardt | Zendy; Nordio Bruna Eliza | Zendy; S. Jenifer | Zendy; Dallegrave Eliane | Zendy; Rossato-Grando Luciana Grazziotin | Zendy; Moura Dinara Jaqueline | Zendy

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Cytotoxic mechanism of Bothrops jararaca venom mediated by mitochondrial depolarization

Author(s) -

Moras Ana Moira,

Luiza Steffens Reinhardt,

Nordio Bruna Eliza,

S. Jenifer,

Dallegrave Eliane,

Rossato-Grando Luciana Grazziotin,

Moura Dinara Jaqueline

Publication year - 2020

Publication title -

advances in toxicology and toxic effects

Language(s) - English

Resource type - Journals

ISSN - 2692-4633

DOI - 10.17352/atte.000007

Subject(s) - bothrops jararaca , venom , bothrops , in vitro , mechanism of action , mechanism (biology) , chemistry , pharmacology , toxicity , cytotoxic t cell , snake venom , biology , biochemistry , philosophy , organic chemistry , epistemology

Background: Snake venoms are natural sources of proteins and peptides with several biological activities. Therefore, this study aimed to evaluate the in vitro toxicity of crude Bothrops jararaca (B. jararaca) venom on different human tumor cells and investigate its action mechanism. Material and methods: The crude venom from B. jararaca was provided by State Foundation for Health Research and Production and Center of Toxicological Information of Rio Grande do Sul, Brazil. To investigate different sensitivities of normal and cancer cell lines, cell viability was measured by using the MTT and neutral red uptake assays.

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