The cellular inflammatory response associated with sulfur mustard induced delayed limbal stem cell deficiency and evaluation of tacrolimus treatment | Zendy

Berg Elina | Zendy; David Zadok | Zendy; Gore Ariel | Zendy; Cohen Maayan | Zendy; Gutman Hila | Zendy; Gez Rellie | Zendy; Horwitz Vered | Zendy; Dachir Shlomit | Zendy; Kadar Tamar | Zendy

Open Access

The cellular inflammatory response associated with sulfur mustard induced delayed limbal stem cell deficiency and evaluation of tacrolimus treatment

Author(s) -

Berg Elina,

David Zadok,

Gore Ariel,

Cohen Maayan,

Gutman Hila,

Gez Rellie,

Horwitz Vered,

Dachir Shlomit,

Kadar Tamar

Publication year - 2019

Publication title -

advances in toxicology and toxic effects

Language(s) - English

Resource type - Journals

ISSN - 2692-4633

DOI - 10.17352/atte.000006

Subject(s) - sulfur mustard , stem cell , inflammatory response , medicine , tacrolimus , nitrogen mustard , corneal neovascularization , neovascularization , limbal stem cell , inflammation , immunology , cornea , ophthalmology , cancer research , surgery , biology , toxicity , corneal epithelium , transplantation , angiogenesis , microbiology and biotechnology , chemotherapy , cyclophosphamide

Purpose: To further investigate the inflammatory response as one of the leading factors in the development of delayed limbal stem cell deficiency, clinically manifested by corneal neovascularization , following sulfur mustard ocular exposure in rabbits and to evaluate potential therapy. Materials and methods: Right eyes of rabbits were exposed to sulfur mustard vapor. Clinical examination was performed and the growth of corneal blood vessels was evaluated. Inflammatory cells (neutrophils, macrophages, antigen-presenting cells and T cells) were identified immunohistochemically. Tacrolimus (Prograf, Teva, 5mg/ml) an immuno-modulator drug, was tested via sub-conjunctival injection (50µl), started either before or after the development of neovascularization (72h and 4weeks, respectively) given once a week for 3weeks.

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