An experimental study targeting N-methyl-D-aspartate receptor in depression; beyond ketamine | Zendy

Salim Sheikh | Zendy; So Pankaj | Zendy; Tripathi Chakar Dhar | Zendy; Verma Veena | Zendy; Bushra Karim | Zendy

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An experimental study targeting N-methyl-D-aspartate receptor in depression; beyond ketamine

Author(s) -

Salim Sheikh,

So Pankaj,

Tripathi Chakar Dhar,

Verma Veena,

Bushra Karim

Publication year - 2020

Publication title -

annals of psychiatry and treatment

Language(s) - English

Resource type - Journals

ISSN - 2640-8031

DOI - 10.17352/apt.000021

Subject(s) - ketamine , depression (economics) , adverse effect , medicine , pharmacology , intensive care medicine , psychiatry , anesthesia , economics , macroeconomics

Presently, the armamentarium of drugs against depression include tricyclic antidepressants, monoamine oxidase inhibitors, norepinephrine and serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs) and atypical anti-depressants [5]. The neurotransmitters targeted are primarily serotonin (5-HT), norepinephrine and dopamine. However, SNRI and SSRI drugs are preferred owing to less adverse effects and low toxicity profi le [6,7].

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