Tubular dysfunction in patients with rheumatoid arthritis

As an indicator of proximal tubular damage is used urinary excretion N-Acetyl-β-D-glucosaminidase (NAG), while Microalbuminuria is used as a tracer for glomerular damage. Aim: The aim of the study is to determined effect of toxicity of these medicals by affecting the enzymuria that correlate with the damage of the epithelium of proximal tubular. To quantifice effects of the treatment with Etoricoxib and Diclofenac on renal proximal tubular in patients with Rheumatoid Arthritis (RA). Methods: NAG is detected with colorimetric method. Microalbuminuria is detected with method od immunoturbidimetric. Tests were performed on 70 participants (35 RA treated with Etoricoxib, 35 RA patients with Diclofenac) in four time intervals in the eight weeks. Results: Correlation between NAG and microalbuminuria (r = 0.21) in the group of patients treated with Etoricoxib is moderate, while correlation (r = 0.28) in the group with Diclofenac was significant. NAG enzymuria, in volume, number of participants in whom it was registered and at the time of its occurrence was much faster during the use of Diclofenac in relation to Etoricoxib. Conclusion: Diclofenac is a potent NAG-inductor and gives a larger tubular enzymuria in comparison with Etoricoxib.