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Alzheimer’s Disease (AD) susceptibility has been soared during global pandemic of coronavirus disease 2019 (COVID-19). People of advanced ages, especially those over sixty years old are more vulnerable to AD and COVID-19 conundrum. Concordant and discordant etiology, pathophysiology and management strategies of AD and COVID-19 had been highlighted in this review. Considering the grave concern of AD and COVID-19 specifi cally on global aged old population, some recommendations for managing both of the crises had been put forward. Mini Review Heightened Vulnerability of Alzheimer’s disease in COVID-19 Cataclysm and Putative Management Strategies Mohammad Azizur Rahman1*, Mohammad Saidur Rahman2 and Nur Alam3 1Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh 2Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh 3Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh Received: 29 October, 2020 Accepted: 25 November, 2020 Published: 27 November, 2020 *Corresponding author: Mohammad Azizur Rahman, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh, E-mail: