Method for Therapeutic Drug Monitoring of Voriconazole and its Primary Metabolite Voriconazole-N-oxide in Human Serum using LC-MS/MS | Zendy

Mendy ter Avest | Zendy; Anette Veringa | Zendy; Kai van Hateren | Zendy; Remco A. Koster | Zendy; Daan J. Touw | Zendy; JanWillem C. Alffenaar | Zendy

Open Access

Method for Therapeutic Drug Monitoring of Voriconazole and its Primary Metabolite Voriconazole-N-oxide in Human Serum using LC-MS/MS

Author(s) -

Mendy ter Avest,

Anette Veringa,

Kai van Hateren,

Remco A. Koster,

Daan J. Touw,

JanWillem C. Alffenaar

Publication year - 2018

Publication title -

journal of applied bioanalysis

Language(s) - English

Resource type - Journals

ISSN - 2405-710X

DOI - 10.17145/jab.18.016

Subject(s) - voriconazole , therapeutic drug monitoring , metabolite , pharmacology , drug , chemistry , chromatography , active metabolite , medicine , antifungal , biochemistry , dermatology

RESULTS: Voriconazole and voriconazole-N-oxide concentrations can be detected with good accuracy and reproducibility within the therapeutic range (ref. 1-6 mg/L). Accuracy ranged from -3.0%-4.2% for voriconazole and -1.0%-3.8% for voriconazole-N-oxide and overall coefficients of variation (CV) ranged from 2.9%-7.5% for voriconazole and 4.0%-10.8% for voriconazole-N-oxide. However, voriconazole-N-oxide is relatively unstable at room temperature (Low QC sample: -81.1% after 120 hours), therefore samples should be cooled (2-8°C) after sampling to detect reliable voriconazole-N-oxide concentrations.

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