Premenapozal Kadınlarda Myoma Uteri Gelişimi Üzerine Visseral/Trunkal Yağ Oranının ve İnsülin Direncinin Etkisinin Değerlendirilmesi

Objectives:  Within the scope of this study, we aimed to analyze the effect of visceral and truncal fat rate and insulin resistance on myoma uteri progression in premenopausal women. Materials and Methods: 100 patients, who have been applied to the gynecology department with myoma diagnosis and 50 control patients who had no myomas and had similar properties with the patient group were included in the study. Anthropometric measures, pre-prandial serum glucose, HbA1c, insulin, LDL-cholesterol, triglyceride, HDL-cholesterol and total cholesterol levels were studied. All statistical analyses were performed with SPSS 16.0 statistical soft-ware and a level of p < 0.05 is accepted statistically significant. Results: Truncal fat rate of the patient group is found higher than the control group (p=0.014). Mean HbA1c was higher and statistically significant (p< 0.001) in the patient group. Mean HDL-C was found significantly lower in the patient group (p= 0.001). Conclusion: In our study, higher levels of truncal fat rate in the patient group can be inferred to the production of estrogen in truncal fat tissue due to increased aromatase activity and thus myoma frequency was increased. We have also determined in this study that higher HbA1c levels in patient group caused an increase in the risk of myoma up to 3.5 times. Normal values of HOMA-IR suggest that insulin resistance is not a risk factor for the development of myoma. It is believed that there is a negative correlation between hyperlipidemia and myoma.