Homeostatic Model Assessment Insulin Resistance (HOMA-IR) Değerleri ile Glomerüler Filtrasyon Hızları Arasındaki İlişki: Retrospektif Bir Çalışma

Aim: Our aim is to evaluate the possible relationships between insulin resistance levels and glomerular filtration rates (GFR) according to Cockcroft-Gault (CG) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. Material and Method: Data of 169 subjects (58 men, 111 women) with a medium age of 39.11±10.29 years were evaluated retrospectively.  The individuals whose body mass index (BMI) value was 30 and over were defined as obese. Homeostatic model assessment insulin resistance (HOMA-IR) value was calculated and the insulin resistance was accepted as positive for patients with HOMA score ≥ 2.7. Glomerular filtration rates were calculated by both Cockcroft-Gault and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. Results: Ninety-four subjects (%55.60) were accepted to be insulin resistant. There were no statistical significance between insulin resistant group and non-resistant group according to age and gender. There was a correlation between HOMA-IR levels and GFR values according to CG equation. There was no correlation between HOMA-IR levels and GFR values according to CKD-EPI equation. According to the GFR values calculated by CG equation, GFR levels were significantly higher in insulin resistant group (152,66±48,90 vs 123,12±34,95 ml/min; p<0.001). Conclusion: Cockcroft-Gault equation is accepted to be influenced by body weight and also BMI which was a predictor of insulin resistance.  According to our findings CG levels can be effected by presence of insulin resistance but such finding was not present in CKD-EPI levels. We thought that this topic is needed to be studied in future researches.