Open AccessH19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.
Author(s) -
Eric J. Devor,
Jill N. DeMik,
Brandon Schickling,
Michael J. Goodheart,
Kimberly K. Leslie
Publication year - 2011
Publication title -
proceedings in obstetrics and gynecology
Language(s) - English
Resource type - Journals
ISSN - 2154-4751
DOI - 10.17077/2154-4751.1101
Subject(s) - endometrium , biology , carcinogenesis , genomic imprinting , serous fluid , placenta , gene , rna , gene expression , cancer research , dna methylation , endocrinology , genetics , pregnancy , fetus , biochemistry
H19 is a maternally expressed noncoding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Over the past fifteen years, however, high H19 expression has been seen in a number of human cancers. Recently, the 2.6kb H19 transcript was shown to be the premiRNA of miR-675 whose target mRNA is the tumor suppressor RB1.
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