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H19 is a maternally expressed noncoding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Over the past fifteen years, however, high H19 expression has been seen in a number of human cancers. Recently, the 2.6kb H19 transcript was shown to be the premiRNA of miR-675 whose target mRNA is the tumor suppressor RB1.

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.