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Acetaminophen toxicity with concomitant use of carbamazepine
Author(s) -
Jickling Glen,
Heino Angela,
Ahmed S. Nizam
Publication year - 2009
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2009.0274
Subject(s) - carbamazepine , toxicity , concomitant , acetaminophen , medicine , anesthesia , pharmacology , epilepsy , psychiatry
Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34‐year‐old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.