Premium
Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizurecontrolling network
Author(s) -
Heida James G.,
Velíšková Jana,
Moshé Solomon L.
Publication year - 2008
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2008.0160
Subject(s) - muscimol , flutamide , endocrinology , medicine , agonist , substantia nigra , androgen receptor , androgen , gabaa receptor , blockade , receptor , pharmacology , biology , hormone , dopamine , dopaminergic , prostate cancer , cancer
The substantia nigra pars reticulata (SNR) controls seizures in a sex‐specific manner. At postnatal day 15 (P15), SNR infusion of GABA A receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0‐P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of procon‐vulsant SNR muscimol responses.