Unilateral progressive osseous heteroplasia | Zendy

Felicidade Santiago | Zendy; Ricardo Vieira | Zendy; Margarida Robalo Cordeiro | Zendy; Óscar Tellechea | Zendy; Américo Figueiredo | Zendy

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Unilateral progressive osseous heteroplasia

Author(s) -

Felicidade Santiago,

Ricardo Vieira,

Margarida Robalo Cordeiro,

Óscar Tellechea,

Américo Figueiredo

Publication year - 2009

Publication title -

european journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.48

H-Index - 71

eISSN - 1952-4013

pISSN - 1167-1122

DOI - 10.1684/ejd.2009.0634

Subject(s) - medicine , gnas complex locus , trunk , family history , osteoma , cutis , pathology , anatomy , surgery , gene , genetics , biology , ecology

A 50-year-old male patient presented with firm subcutaneous nodules and plaques with a gritty texture, unilaterally affecting the left side of the trunk and the left limbs. These lesions had had a progressive course since early childhood and caused functional impairment. There was no family history of similar disorders. No phospho-calcium metabolism abnormalities were observed. Biopsies of the affected areas demonstrated osteoma cutis. Analysis of DNA showed no mutation of the GNAS gene. The clinical features were consistent with progressive osseous heteroplasia, atypically presented in a unilateral form, probably revealing a mosaic distribution.

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