Open AccessEffects of angiotensin II on endothelial cell growth
Author(s) -
Mercedes Montón,
María Ángeles Castilla,
M V Alvarez Arroyo,
Dunyong Tan,
Francisco R. GonzálezPacheco,
Antonio LópezFarré,
Santiago Casado,
Carlos Caramelo
Publication year - 1998
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.v96969
Subject(s) - losartan , angiotensin ii , vascular smooth muscle , receptor , endothelial stem cell , endocrinology , medicine , angiotensin receptor , cell growth , endogeny , mediator , chemistry , renin–angiotensin system , microbiology and biotechnology , blockade , pharmacology , biology , smooth muscle , biochemistry , in vitro , blood pressure
Angiotensin II (AngII) is a main mediator in the regulation of vascular tone. Although its effects on vascular smooth muscle cells are well known, data on its role on endothelial biology are still insufficient. The present study examined the effect of endogenous and exogenous AngII on bovine aortic endothelial cells possessing both AT-1 and AT-2 receptors. A DNA synthesis-promoting effect of AT-2 blockade by PD123319 (10(-9) to 10(-7) M) was demonstrated. This effect was transduced through an AT-1-mediated pathway, as shown by using the AT-1 antagonist, losartan. In addition, an AT-1-mediated effect of AngII was demonstrated on bovine aortic endothelial cell proliferation, which occurred despite the absence of AngII-induced Ca2+ transients. In summary, the present study disclosed relevant characteristics of the effect of AngII on endothelial cell growth that have potential pathophysiologic projections, particularly for the use of selective AngII blocking agents.
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