Ketoconazole activates chloride and fluid secretion by Necturus gallbladder at low pH. | Zendy

U. Kersting | Zendy; K. R. Spring | Zendy

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Ketoconazole activates chloride and fluid secretion by Necturus gallbladder at low pH.

Author(s) -

U. Kersting,

K. R. Spring

Publication year - 1996

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v72254

Subject(s) - necturus , chemistry , apical membrane , sodium , epithelium , potassium , secretion , biophysics , endocrinology , medicine , gallbladder , chloride , membrane , biochemistry , biology , organic chemistry , genetics

Necturus gallbladder epithelium, normally a reabsorptive epithelium, was stimulated to secrete chloride and fluid by the combined effects of ketoconazole and a reduction in perfusate pH to 7.0. The reversal in the direction of net fluid transport was accompanied by inhibition of the conductance of the apical cell membrane to sodium, potassium, and a striking stimulation of the conductance to chloride. The results are consistent with a previously unidentified mechanism for regulation of the apical cell membrane transport properties of reabsorptive epithelia.

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