Insulin-like growth factor-I receptor and binding proteins in rat kidney after nephron loss. | Zendy

Michael K. Hise | Zendy; Joel S. Lahn | Zendy; ZhiMing Shao | Zendy; Nicki M. Mantzouris | Zendy; Joseph A. Fontana | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Insulin-like growth factor-I receptor and binding proteins in rat kidney after nephron loss.

Author(s) -

Michael K. Hise,

Joel S. Lahn,

ZhiMing Shao,

Nicki M. Mantzouris,

Joseph A. Fontana

Publication year - 1993

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v4162

Subject(s) - medicine , endocrinology , nephron , kidney , convoluted tubule , glomerulus , insulin like growth factor , renal glomerulus , biology , receptor , insulin like growth factor binding protein , growth factor , chemistry , glomerulonephritis

Insulin-like growth factor (IGF)-binding proteins and the IGF-I receptor in rat kidney were studied to gain perspective on their potential roles in the control of renal cell mass. Thirty days after nephrectomy (UNx), membranous whole-kidney binding of IGF-I averaged 9.5 +/- 1.0 pmol/kidney, whereas binding to sham-operated controls (SNx) averaged 6.3 +/- 0.8 pmol/kidney (N = 6; P 200,000 d, and a protein approximately 31,000 d that was immunostained with IGF-binding protein-5 antibodies. Differences in expression between SNx and UNx were not observed at Day 30 in either glomeruli or BLM. These studies suggest that cytosolic hypertrophy of proximal nephron structures is accompanied by membrane hypertrophy with a fixed density of IGF-I receptor and IGF-binding protein-5.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research