Atrial natriuretic peptide suppresses compensatory renal growth in rats. | Zendy

Jean Logan | Zendy; U F Michael | Zendy

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Atrial natriuretic peptide suppresses compensatory renal growth in rats.

Author(s) -

Jean Logan,

U F Michael

Publication year - 1994

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v4122016

Subject(s) - atrial natriuretic peptide , medicine , endocrinology , kidney , in vivo , natriuretic peptide , renal function , biology , chemistry , heart failure , microbiology and biotechnology

Atrial natriuretic peptide (ANP) inhibits the growth of a variety of cell types in vitro including mesangial cells. The effects of ANP on the growth of the kidney in vivo were evaluated. A 2-h infusion of 0.2 microgram/250 g body wt per minute of ANP suppressed the subsequent uptake of [3H]thymidine into the renal DNA of uninephrectomized but not intact rats. This treatment also depressed the ratio of RNA/DNA in kidneys undergoing compensatory growth. Correlative physiologic studies revealed enhanced GFR in rats with two kidneys infused with ANP, but no increase in the GFR of uninephrectomized rats. It was concluded that ANP may oppose the growth factor(s) mediating compensatory renal growth.

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