Immunocytochemical localization of sodium-calcium exchanger in canine nephron. | Zendy

J. E. Bourdeau | Zendy; A N Taylor | Zendy; Anthony M. Iacopino | Zendy

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Immunocytochemical localization of sodium-calcium exchanger in canine nephron.

Author(s) -

J. E. Bourdeau,

A N Taylor,

Anthony M. Iacopino

Publication year - 1993

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v41105

Subject(s) - sarcolemma , calcium , sodium calcium exchanger , sodium , nephron , chemistry , endocrinology , medicine , biophysics , kidney , biology , biochemistry , membrane , organic chemistry

The sodium-calcium exchanger was localized in tissue sections of canine kidneys with two different polyclonal antisera raised against purified sodium-calcium exchanger protein derived from dog cardiac sarcolemma. The sodium-calcium exchanger was prominent in the basolateral plasmalemma of the majority of cells in all connecting tubules. In contrast, it was observed rarely and inconspicuously over the basolateral aspects of proximal tubular cells. The sodium-calcium exchanger was undetectable in all other portions of the nephron.

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