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Proton nuclear magnetic resonance spectroscopy was performed on blood or urine from five patients with an anion-gap metabolic acidosis. In all of these cases, this methodology allowed the rapid and specific diagnosis of the nature of the metabolic acidosis. In several of these patients, spectroscopic evidence for intoxication with toxic alcohols was obtained. On the basis of these preliminary data, proton nuclear magnetic resonance spectroscopy may be a useful technique in the evaluation of patients with anion-gap acidosis.

Nuclear magnetic resonance spectroscopy in patients with anion-gap acidosis.