Rise in Albuminuria and Blood Pressure in Patients Who Progressed to Diabetic Nephropathy in the Diabetes Control and Complications Trial | Zendy

William J. Thomas | Zendy; Yingjia Shen | Zendy; Mark E. Molitch | Zendy; Michael W. Steffes | Zendy

Open Access

Rise in Albuminuria and Blood Pressure in Patients Who Progressed to Diabetic Nephropathy in the Diabetes Control and Complications Trial

Author(s) -

William J. Thomas,

Yingjia Shen,

Mark E. Molitch,

Michael W. Steffes

Publication year - 2001

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v122333

Subject(s) - medicine , albuminuria , diabetic nephropathy , diabetes mellitus , nephropathy , blood pressure , endocrinology , surgery , urology , cardiology

. The Diabetes Control and Complications Trial (DCCT) enrolled 1441 participants to address the role of intensive therapy for type 1 diabetes mellitus on the onset and progression of microvascular complications. To examine the timing of elevated systolic BP (SBP) and diastolic BP (DBP) and increased albumin excretion rate (AER) in the progression to clinical diabetic nephropathy (AER > 300 mg/24 h on two consecutive visits from a baseline of 300 mg/24 h. These results underline the early and prognostic rise in AER in diabetic patients, but only in those who received conventional treatment. The evolution of diabetic renal disease may follow a different course in patients who receive intensive diabetic treatment.

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