Nicotinic Acid Adenine Dinucleotide Phosphate | Zendy

Jingfei Cheng | Zendy; Ahad N.K. Yusufi | Zendy; Michael A. Thompson | Zendy; Eduardo N. Chini | Zendy; Joseph P. Grande | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nicotinic Acid Adenine Dinucleotide Phosphate

Author(s) -

Jingfei Cheng,

Ahad N.K. Yusufi,

Michael A. Thompson,

Eduardo N. Chini,

Joseph P. Grande

Publication year - 2001

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.v12154

Subject(s) - biochemistry , inositol , inositol trisphosphate , intracellular , microsome , chemistry , nicotinamide adenine dinucleotide phosphate , inositol phosphate , mesangial cell , nicotinic agonist , biology , receptor , in vitro , enzyme , oxidase test

. Nicotinic acid adenine dinucleotide phosphate (NAADP), a molecule derived from β-NADP, has been shown to trigger Ca 2+ release from intracellular stores of invertebrate eggs and mammalian cell microsomes. NAADP-induced Ca 2+ release occurs through a mechanism distinct from that of inositol-1,4,5-trisphosphate— or cyclic ADP-ribose—elicited Ca 2+ release. This study investigated whether NAADP can be synthesized in rat kidney. Extracts from glomeruli, mesangial cells, and papilla have high NAADP synthetic capacities. Conversely, synthesis of NAADP in kidney cortex was almost undetectable. Furthermore, 9- cis -retinoic acid significantly up-regulated NAADP synthesis in mesangial cells. Authenticity of NAADP biosynthesis in glomeruli was affirmed by HPLC analysis. NAADP stimulated Ca 2+ release from mesangial cell microsomes through a pathway distinct from that of inositol-1,4,5-trisphosphate or cyclic ADP-ribose. NAADP-triggered Ca 2+ release may play an important role in regulation of renal function.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research