Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2–Mediated Blood Pressure Reduction Independent of Cystogenesis | Zendy

Jayalakshmi Lakshmipathi | Zendy; Yang Gao | Zendy; Chunyan Hu | Zendy; Deborah Stuart | Zendy; Jonathan R. Genzen | Zendy; Nirupama Ramkumar | Zendy; Donald E. Kohan | Zendy

Open Access

Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2–Mediated Blood Pressure Reduction Independent of Cystogenesis

Author(s) -

Jayalakshmi Lakshmipathi,

Yang Gao,

Chunyan Hu,

Deborah Stuart,

Jonathan R. Genzen,

Nirupama Ramkumar,

Donald E. Kohan

Publication year - 2020

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2019090934

Subject(s) - nephron , blood pressure , cyclooxygenase , reduction (mathematics) , endocrinology , medicine , chemistry , kidney , biochemistry , enzyme , mathematics , geometry

Hypertension often occurs before renal function deteriorates in autosomal dominant polycystic kidney disease (ADPKD). It is unknown whether the Pkd1 gene product polycystin-1-the predominant causal factor in ADPKD-itself contributes to ADPKD hypertension independent of cystogenesis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research