Open AccessSingle-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation
Author(s) -
Sébastien J. Dumas,
Elda Meta,
Mila Borri,
Jermaine Goveia,
Kateřina Rohlenová,
Nadine V. Conchinha,
Kim D. Falkenberg,
Laure-Anne Teuwen,
Laura de Rooij,
Joanna Kalucka,
Rongyuan Chen,
Shawez Khan,
Federico Taverna,
Weisi Lu,
Magdalena Parys,
Carla De Legher,
Stefan Vinckier,
Tobias K. Karakach,
Luc Schoonjans,
Lin Lin,
Lars Bolund,
Mieke Dewerchin,
Guy Eelen,
Ton J. Rabelink,
Xuri Li,
Yonglun Luo,
Peter Carmeliet
Publication year - 2019
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2019080832
Subject(s) - kidney , biology , renal medulla , endothelial stem cell , homeostasis , endothelium , endocrinology , medicine , microbiology and biotechnology , biochemistry , in vitro
This study provides a high-resolution atlas of the renal endothelium and highlights extensive renal endothelial cell phenotypic heterogeneity, as well as a previously unrecognized role of oxidative phosphorylation in the metabolic adaptation of medullary renal endothelial cells to water deprivation.
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