A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease
Author(s) -
Fan Fan,
Aron M. Geurts,
Mallikarjuna R. Pabbidi,
Ying Ge,
Chao Zhang,
Shaoxun Wang,
Yedan Liu,
WenJun Gao,
Ya Guo,
Longyang Li,
Xiaochen He,
Wenshan Lv,
Yoshikazu Muroya,
Takashi Hirata,
Jeremy W. Prokop,
George W. Booz,
Howard J. Jacob,
Richard J. Roman
Publication year - 2020
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2019080784
Subject(s) - medicine , endocrinology , kidney disease , kidney , knockout mouse , mutation , biology , renal function , pathology , genetics , gene , receptor
The genes and mechanisms involved in the association between diabetes or hypertension and CKD risk are unclear. Previous studies have implicated a role for γ -adducin (ADD3), a cytoskeletal protein encoded by Add3 .
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