A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis | Zendy

Yue Shi | Zendy; Xiaoyu Jia | Zendy; Qiuhua Gu | Zendy; Miao Wang | Zendy; Zhao Cui | Zendy; MingHui Zhao | Zendy

Open Access

A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis

Author(s) -

Yue Shi,

Xiaoyu Jia,

Qiuhua Gu,

Miao Wang,

Zhao Cui,

MingHui Zhao

Publication year - 2019

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2019010067

Subject(s) - epitope , autoantibody , peptide , type iv collagen , basement membrane , glomerular basement membrane , goodpasture syndrome , glomerulonephritis , antigen , antibody , chemistry , autoimmunity , immunology , microbiology and biotechnology , biology , biochemistry , kidney , cell , endocrinology , laminin

In Goodpasture disease, the noncollagenous domain 1 of the α 3 chain ( α 3NC1) of type IV collagen is the main target antigen of antibodies against glomerular basement membrane (GBM). We previously identified a nephritogenic epitope, P14 ( α 3 127-148 ), that could induce crescentic nephritis in WKY rats, and defined its core motif. Designing a modified peptide, replacing critical pathogenic residues with nonpathogenic ones (on the basis of homologous regions in α 1NC1 chain of type IV collagen, known to be nonpathogenic), might provide a therapeutic option for anti-GBM GN.

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