The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus | Zendy

Manuel Chiusa | Zendy; Wen Hu | Zendy; HongJun Liao | Zendy; Yan Ru Su | Zendy; Corina M. Borza | Zendy; Mark P. de Caestecker | Zendy; Nataliya Skrypnyk | Zendy; Agnes B. Fogo | Zendy; Vadim Pedchenko | Zendy; Xiyue Li | Zendy; MingZhi Zhang | Zendy; Billy G. Hudson | Zendy; Trayambak Basak | Zendy; Roberto Vanacore | Zendy; Roy Zent | Zendy; Ambra Pozzi | Zendy

Open Access

The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus

Author(s) -

Manuel Chiusa,

Wen Hu,

HongJun Liao,

Yan Ru Su,

Corina M. Borza,

Mark P. de Caestecker,

Nataliya Skrypnyk,

Agnes B. Fogo,

Vadim Pedchenko,

Xiyue Li,

MingZhi Zhang,

Billy G. Hudson,

Trayambak Basak,

Roberto Vanacore,

Roy Zent,

Ambra Pozzi

Publication year - 2019

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2018111160

Subject(s) - ddr1 , discoidin domain , collagen receptor , receptor tyrosine kinase , microbiology and biotechnology , biology , chemistry , receptor , signal transduction , integrin , biochemistry

The discoidin domain receptor 1 (DDR1) is activated by collagens, upregulated in injured and fibrotic kidneys, and contributes to fibrosis by regulating extracellular matrix production, but how DDR1 controls fibrosis is poorly understood. DDR1 is a receptor tyrosine kinase (RTK). RTKs can translocate to the nucleus via a nuclear localization sequence (NLS) present on the receptor itself or a ligand it is bound to. In the nucleus, RTKs regulate gene expression by binding chromatin directly or by interacting with transcription factors.

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