Open AccessContribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes
Author(s) -
Onur K. Polat,
Masatoshi Uno,
Terukazu Maruyama,
Ha Nam Tran,
Kayo Imamura,
Chee Fah Wong,
Reiko Sakaguchi,
Mariko Ariyoshi,
Kyohei Itsuki,
Jun Ichikawa,
Takashi Morii,
Masahiro Shirakawa,
Ryuji Inoue,
Katsuhiko Asanuma,
Jochen Reiser,
Hidehito Tochio,
Yasuo Mori,
Masayuki Mori
Publication year - 2019
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2018070756
Subject(s) - calmodulin , trpc6 , coiled coil , phenotype , microbiology and biotechnology , biology , chemistry , genetics , medicine , calcium , transient receptor potential channel , receptor , gene
TRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with TRPC6 current amplitude amplification and/or delay of the channel inactivation (gain-of-function phenotype). However, the mechanism of the gain-of-function in TRPC6 activity has not yet been clearly solved.
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