Open AccessInhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice
Author(s) -
Kenichi Ishizawa,
Qin Wang,
Jinping Li,
Ning Xu,
Yoshikazu Nemoto,
Chikayuki Morimoto,
Wataru Fujii,
Yoshifuru Tamura,
Yoshihide Fujigaki,
Kazuhisa Tsukamoto,
Toshiro Fujita,
Shunya Uchida,
Shigeru Shibata
Publication year - 2019
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2018070703
Subject(s) - cotransporter , phosphorylation , microbiology and biotechnology , biology , serine , kinase , medicine , endocrinology , chemistry , sodium , organic chemistry
Mechanisms underlying the frequent association between salt-sensitive hypertension and type 2 diabetes remain obscure. We previously found that protein kinase C (PKC) activation phosphorylates Kelch-like 3 (KLHL3), an E3 ubiquitin ligase component, at serine 433. We investigated whether impaired KLHL3 activity results in increased renal salt reabsorption via NaCl cotransporter (NCC).
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