Leveraging Ancestral Heterogeneity to Map Shared Genetic Risk Loci in Pediatric Steroid-Sensitive Nephrotic Syndrome | Zendy

Rebecca Hjorten | Zendy; Karl Skorecki | Zendy

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Leveraging Ancestral Heterogeneity to Map Shared Genetic Risk Loci in Pediatric Steroid-Sensitive Nephrotic Syndrome

Author(s) -

Rebecca Hjorten,

Karl Skorecki

Publication year - 2018

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2018050465

Subject(s) - nephrotic syndrome , candidate gene , allele , genetics , disease , biology , bioinformatics , epistasis , focal segmental glomerulosclerosis , phenotype , medicine , gene , endocrinology , glomerulonephritis , kidney

Nephrotic syndrome is the most common glomerular disease in childhood, with a prevalence of 16 patients per 100,000 children. Approximately 80% will have steroid-sensitive nephrotic syndrome (SSNS); 50% of those will be frequently relapsing or steroid dependent, with some requiring additional

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