Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A | Zendy

Rainer Schreiber | Zendy; Bjoern Buchholz | Zendy; Andre Kraus | Zendy; Gunnar Schley | Zendy; Julia Katharina Scholz | Zendy; Jiraporn Ousingsawat | Zendy; Karl Kunzelmann | Zendy

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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

Author(s) -

Rainer Schreiber,

Bjoern Buchholz,

Andre Kraus,

Gunnar Schley,

Julia Katharina Scholz,

Jiraporn Ousingsawat,

Karl Kunzelmann

Publication year - 2019

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2018010039

Subject(s) - lipid peroxidation , polycystic kidney disease , cystic fibrosis transmembrane conductance regulator , endocrinology , medicine , chloride channel , oxidative stress , cyst , reactive oxygen species , kidney , microbiology and biotechnology , biology , chemistry , pathology , cystic fibrosis

Transepithelial chloride - secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure.

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