Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF-β Receptor: A New Twist on an Old Paradigm | Zendy

David P. Basile | Zendy; Purvi Mehrotra | Zendy

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Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF-β Receptor: A New Twist on an Old Paradigm

Author(s) -

David P. Basile,

Purvi Mehrotra

Publication year - 2017

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2017080947

Subject(s) - fibrosis , transforming growth factor , extracellular matrix , myofibroblast , growth factor , cancer research , medicine , pathology , microbiology and biotechnology , biology , receptor

Tubulointerstitial fibrosis has long been recognized as the most significant structural lesion associated with the development and progression of CKD. Since the pioneering work of Border and Ruoslahti,[1][1] the pleiotropic factor TGF- β has assumed a central role in the genesis of

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