Human Kidney Cell Reprogramming | Zendy

Adam C. O’Neill | Zendy; Sharon D. Ricardo | Zendy

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Human Kidney Cell Reprogramming

Author(s) -

Adam C. O’Neill,

Sharon D. Ricardo

Publication year - 2013

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2012121199

Subject(s) - induced pluripotent stem cell , reprogramming , embryonic stem cell , regenerative medicine , disease , biology , neuroscience , kidney disease , stem cell , bioinformatics , medicine , cell , microbiology and biotechnology , pathology , genetics , endocrinology , gene

The ability to reprogram fully differentiated cells into a pluripotent embryonic state, termed induced pluripotent stem cells (iPSCs), has been met with great excitement. iPSC technology has advanced the fundamental study of disease modeling with the potential for cell-replacement therapy, especially in the neuronal and cardiac fields. However, renal medicine as of yet has not benefited from similar advancements. This review summarizes the unique characteristics of iPSCs and their potential applications for modeling kidney disease. Pioneering such endeavors could yield constructs that recapitulate disease phenotypes, open avenues for more targeted drug development, and potentially serve as replenishable sources for replacement of kidney cells in the setting of human disease.

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